“Major morphological alterations of Golgi ribbon disassembly under physiological and pathological conditions during mitosis , differentiation and disease progression”.
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Written by :
SAPTARSHI BHATTACHARYYA
Golgi ribbon can undergo distinct disassembly processes that reflect the cellular state or environmental demands and stress. It can also be detached and positioned at specific cellular locations to gain additional functionalities during differentiation, or fragmented to different degrees along disease progression or upon cell death .
In this article,
unknown areas in this realm has been pointed out so that these can open the
path for new disruptive innovations.
1) The reason why the
Golgi ribbon is disassembled in animal mitosis is still shrouded.
2) The extent of
interdependency and redundancy of the multi-step mitotic golgi disassembly mechanism demands further
investigation.
3) The precise
surveillance cascade that halts mitotic entry need molecular level affirmation.
4) Scientific proof if Golgi satellites are
indeed golgi elements derived from somatic ribbon-their exact ultrastucture and
how they relate to golgi outposts demand serious clarifications.
5) Clarifications are required if the mechanisms that drive Golgi ribbon disassembly in mitosis or
differentiation are also under- pinning Golgi fragmentation during disease
progression.
6) In skeletal muscle, microtubules are nucleated from the Golgi and
nuclear membranes . It is still
unclear if dysregulation of these membrane-associated microtubules may lead to
defective organization and thus alter muscle function.
If
the above obscurities are addressed , mammalian cells
can expand its functionality by refining or disabling it at specific time and place. Ribbon disassembly
could benefit the organism as a whole by meeting the needs for local secretion
in specialized cells. On the other hand, it could also be the
backstage driving force and/or the outcome of several notorious diseases.
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